Junior Research Fellow JRF in a SERB Funded Project

Applications are invited for the post of Junior Research Fellow (JRF) in a SERB-funded research project entitled "A Divergent Strategy for the Asymmetric Total Synthesis of Biologically Active Tetrahydroquinoline and Indole Terpenoids Aspernomine and Tubingensin A" under the supervision of Dr. Santanu Ghosh, Department of Chemistry, School of Natural Sciences, Shiv Nadar Institution of Eminence, Delhi NCR.
Eligible and interested candidates should send their application with a complete CV (having personal and academic details, academic qualifications, research experiences, publications, name, affiliation, and email address of at least two referees) to Dr. Santanu Ghosh (santanu.ghosh@snu.edu.in) on or before 25 September 2024. The scanned copies of mark sheets/transcripts/testimonials/ certificates, a recent passport-size photograph, and other relevant documents are also requested to be attached. Short-listed candidates will be communicated for an online interview.
Project Synopsis
The rich structural diversity of the tetrahydroquinoloine and indole-based diterpene alkaloids are valuable sources of traditional drugs, pharmaceuticals, and ideas for developing new synthetic strategies and methodologies in chemical synthesis. A study of fungal sclerotia of the genus Aspergillus led to the isolation of several biologically active secondary metabolites, including the complex indole- and tetrahydroquinoline-based diterpenoids. Such as anominine, aflavinine, 17-hydroxyeujindole, tubingensin A, and aspernomine have demonstrated various biological activities such as anti-insecticidal activity, significant cytotoxicity against three human solid tumor cell lines, and in vitro antiviral activity against herpes simplex virus type 1. Because of the pharmacological potential and the highly diverse as well as complex architecture of these natural products, they have emerged as influential targets for total synthesis. Herein, we proposed to develop the short route entry to this class of alkaloids:
Objectives

• A unified strategy will be investigated for the synthesis of various bioactive tetrahydroquinoline and indole-based diterpene alkaloids.
• The main emphasis of the synthesis is the discovery of new reaction-based strategies to maintain step and atom economic pathways.
• Some strategic organic transformations such as vinylogous ester synthesis, cross-coupling reaction, dearomatization reaction, and α-amination of ketone will be followed to complete the target molecules.
• Detailed mechanistic investigation thorough structural analysis using NMR studies, IR spectroscopy, mass spectrometry, and density functional theory (DFT) computations will also be carried out to elaborate on the origin of reactivity and selectivity for the key reactions.

Nature of work
This project's initial part would be synthesizing the potential key intermediate. Later on, that intermediate will be applied for the synthesis of various tetrahydroquinoloine and indole-based diterpene alkaloids. A strategy-based multistep organic synthetic protocol will be followed to complete the target molecules.
Essential and Desirable Qualifications

• The candidate should have a Master's degree (with a minimum of 55% marks or equivalent grade) in Chemistry from a UGC-recognized University or Institution.
• The candidate should have good analytical and communication skills.
Candidates having an interest in multistep organic synthesis are encouraged to
• .
• Experiences in organic synthesis and their characterizations will be preferred.
Candidates with CSIR/UGC-NET/JEST/GATE are encouraged to
• .

Duration of the Project
One year (purely temporary).
Fellowship
As per DST norms, the fellowship is ?31,000/- p.m. plus HRA.
Application deadline: 25 September 2024
About Shiv Nadar Institution of Eminence (SNIo E)
Shiv Nadar Institution of Eminence (www.snu.edu.in) is a student-centric, multidisciplinary and research-focused University offering a wide range of academic programs at the Undergraduate, Master's and Doctoral levels. The University was set up in 2011 by the Shiv Nadar Foundation, a philanthropic foundation established by Mr. Shiv Nadar, founder of HCL. The University is on the quest to become a globally acclaimed center for learning and innovation in the fields of Engineering, Natural Sciences, Humanities & Social Sciences, and Management. The core of the University consists of a select, world-class faculty with doctoral and postdoctoral experiences from ranked universities worldwide.
Shiv Nadar Institution of Eminence has recently been selected as one of the ten private Institutions of Eminence by the Government. In the NIRF (Government's National Institutional Ranking Framework), the University has been the youngest institution in the 'top 100' Overall list. In NIRF-2024, it ranked 62 in the 'University' category. Shiv Nadar University has been accredited with a Grade ' A ' by NAAC (National Assessment and Accreditation Council), valid for five years from 26 November 2019. It is also among a select group of greenfield institutions in the country that was awarded the prestigious Atal Incubation Center grant by the NITI Aayog, Government of India, in the very first round in 2017.
The Department of Chemistry is committed to pursuing research on fundamental and applied problems through an interdisciplinary research approach. The Department of Chemistry has state-of-the-art laboratory infrastructure and instrumental facilities for organic and material characterization and application. The department has been ranked among the Top 27 in India in the Nature Index.