Netherlands Job Openings
Erasmus MC
PhD candidate for the project ''Characterization of fusion inhibitory peptides against measles virus''
Rotterdam
September 5, 2024
Ph D candidate for the project ''Characterization of fusion inhibitory peptides against measles virus''
Job description
Respiratory viruses are omnipresent, affecting global health and causing economic losses. Development of novel intervention strategies to combat these viruses is essential. The most recent example underlining this importance is the recent COVID-19 pandemic.Despite the availability of safe and effective measles vaccines, the global incidence of measles is on the rise. Vaccine hesitancy is an important underlying problem, but there are other factors that contribute to the resurgence of measles. Since measles vaccines contain live-attenuated measles virus, patients with severe immunodeficiencies cannot be vaccinated. In addition, there is a so-called immunity gap: a period during which infants (6-14 months) have lost their maternal antibodies but are not yet eligible for vaccination and therefore susceptible to measles.
Together with collaborators in the US, we are evaluating specific antiviral peptides that can interfere with the membrane fusion between virus and target cell, thereby preventing virus infection. In initial proof-of-concept studies we have shown that these fusion inhibitory peptides can prevent measles virus infection in vitro.
In this project, the Ph D candidate will help with the design of peptides and will design and perform experiments to demonstrate in vivo efficacy of these peptides. Additionally, the Ph D candidate will work on improvements of the peptides with regards to solubility, toxicity, stability, and biodistribution.
In these studies, the candidate will use state-of-the-art techniques, including (primary) cell culture, flow cytometry, comprehensive data-set analysis, multicolor confocal microscopy, immunological assays, virus culture, and animal experiments in a BSL-2 and -3 environment.
Work environment
A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.The Department of Viroscience at Erasmus MC employs over 180 FTE and exists of the unit Clinical Virology and the unit Research. Within the Clinical Virology unit, viral diagnostics are conducted for patient care within the Netherlands and internationally. The unit focuses on continuous development of new and improved diagnostic methods, as well as patient-centred topics such as antiviral resistance, viral pathogenesis, and the effectiveness of antiviral therapy. The unit Research harbors different disciplines and runs an extensive research program on the epidemiology, pathogenesis, prevention, and treatment of infections by human and animal viruses. The clinical studies are performed in close collaboration between the two units.
Qualifications and skills
We are looking for a Ph D student who is enthusiastic and highly motivated. In addition you:- Must hold an MSc degree or equivalent from an accredited academic program in biology, biomedical or molecular sciences, or (veterinary) medicine.
- Must be able to obtain a certificate of good conduct and are expected to complete your Ph D within 4 years.
- Must have an excellent command of the English language, both oral and written.
- Need to have a demonstrable affinity with the techniques described in the job description and be willing to work with human tissues, primary cells, and experimental animals in BSL-2 and BSL-3 environments.
Before you apply please check our conditions for employment.
Terms of employment
- You will receive a temporary position for 4 years.
- The gross monthly salary is € 3.017,- in the 1st year and increases to € 3.824,- in the 4th year (scale OIO).
- excellent fringe benefits, such as a 13th month that is already paid out in November and an individual travel expense package.
- An International Office which aids you in preparing for you arrival and stay.
- Pension insurance with ABP, we take care of 70% of the monthly contribution.
- Special benefits, such as an in-company physiotherapist and bicycle repairer. There is also a gym where you can work on your fitness after work.
More information
For more information about this position, please contact Dr. Rory D. de Vries, Associate Professor, department of Viroscience, +316 421 279 10.If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.
No agencies please.
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