About the job
Pharma Essentia strives to develop first-in-class and best-in-class biotherapeutics, including cytokines, antibodies, and antibody-drug-conjugates (ADCs), with a novel mechanism of action. To this end, we are seeking a highly skilled and experienced ADC Chemistry leader to join our Taipei Headquarter R&D team. The successful candidate should possess extensive knowledge and experience in ADC design and development. They will be responsible for designing and synthesizing novel linker-payloads. Background in structure-based drug discovery and leading cross-functional project teams are critical for this position. This position is based in Taipei, Taiwan. Sponsorship and other benefits available for suitable candidate willing to relocate from US to Taiwan!

Responsibilities

• Establish discovery stage ADC linker-payload and bioconjugation lab capabilities, focusing on the design and synthesis of novel linker-payload molecules.
• Manage a cross-functional team of scientists, including medicinal chemists and analytical chemists, creating a collaborative and results-driven work environment while maintaining high safety standards.
• Contribute to Pharma Essentia ADC linker-payload strategy and utilize experience in synthetic chemistry and methodology to execute and optimize synthetic routes for efficient and scalable production of linker-payloads.
• Characterize and analyze synthesized molecules using analytical techniques such as HPLC, LC-MS and NMR.
• Collaborate with cross-functional teams to support ADC projects from discovery to non-clinical and clinical development.
• Stay current with the latest developments in ADC chemistry and the latest regulatory requirements governing ADC development and manufacturing, including GMP guidelines.

Qualification

• Ph.D. in synthetic or medicinal chemistry with a minimum of 12 years of related experience with expert working knowledge of the key medicinal chemistry concepts and design tools.
• Minimum 4 years’ experience of ADC drug discovery, and well-versed in all aspects of ADC linker-payload design, synthesis, evaluation, and bioconjugation development.
• Proven accomplishments in medicinal chemistry, with operational skills for managing discovery programs at the level of a Senior Chemist/Team Leader or above.
• A history of delivering multiple clinical candidates proven by successful publications, patents, and contribution in the field of small molecule drug discovery.
• Solid understanding of cellular/molecular biology, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmacokinetic and pharmacodynamic sciences for the in vivo evaluation of drug candidates.
• Expert knowledge of modern methods of synthetic organic chemistry with ability to conduct medicinal chemistry drug discovery successfully and simultaneously on multiple projects
• Excellent communication to develop effective partnerships, lead cross functional teams, and delegate work effectively to team members.

Preferred Qualification

• Familiarity with bioconjugation, purification and characterization processes relevant to ADC development and manufacturing.
• Knowledge of critically relevant areas such as analytical characterization, formulation, and the general CMC scope of ADC and biologics.
• Experience in developing and validating bioanalytical methods for ADC, including ligand binding assays, ELISA, Immunogenicity (ADA and NBA assays), and other relevant techniques.

At Pharma Essentia, our goal is to treat as many people with cancer as possible. That means challenging the status quo with better science that leads to better lives. By joining our team, you will not only expand your own possibilities, but you will contribute to expanding options for people with cancer.
https://us.pharmaessentia.com/careers/

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