Belgium Job Openings

KU Leuven

PhD Position: Implantable biosensors for neurotransmitter monitoring

Leuven

FULL TIME

September 12, 2024

Ph D Position: Implantable biosensors for neurotransmitter monitoring
(ref. BAP-2024-573)
Laatst aangepast: 19/08/24
This doctoral project will be carried out in the frame of a multidisciplinary research project, where expertise in soft-matter physics, nanobiosensing and neurotechnologies is combined with advanced expertise in neurophysiology, and in mechanisms of psychiatric and neurological disorders. While the main part of the work concerns sensor development and validation in vitro in the Nanobiophysics team of the Soft Matter and Biophysics unit of the Department of Physics and Astronomy, under the supervision of Prof Carmen Bartic (Department of Physics and Astronomy), the devices will be customized and tested in vivo in collaboration the neuroscience teams under the supervision of Prof. Myles Mc Laughlin (Department of Neurosciences) and Prof. Rudi D’Hooge and Dr. Laura Luyten (Faculty of Psychology).
The Nanobiophysics team has expertise in biosensors, nanotechnologies and neuroengineering methods. Our main research teams are artificial extracellular matrices and implantable biosensors based on hybrid nano-biomaterials that preserve implant functionality (by reducing inflammation and foreign body response) and add biosensing functionalities to neural prostheses.
Website van de eenheid
Project
Neurons in the brain communicate via complex electrochemical signalling processes that underpin the functioning of the nervous system. Electrochemical signaling allows neurons to form simple local circuits that in turn form vast neural networks to facilitate complex functions such as learning, memory, emotions, and cognition. Recent advances in silicon probe technology allow in vivo electrical recordings with unprecedented throughput and spatio-temporal resolution. However, an equivalent technology for monitoring chemical signalling in a similar way is still missing.
A large variety of electrochemical sensors have been demonstrated in vitro, with proof-of-concept neurotransmitter sensitivities down to nanomole concentrations and millisecond time resolution. However, the huge potential of these methods remains essentially unexploited in vivo, mainly because of: (1) inflammation and foreign body reactions (FBR) that lead to sensor fouling and loss of sensing functionality in chronic settings; (2) instability of conventional Ag/Ag Cl reference electrodes in vivo; (3) poor sensor selectivity in a complex biochemical environment.
The main goal of the project is to tackle these challenges and develop electrochemical biosensors with high sensitivity and selectivity for fast and multiplexed in vivo neurochemical monitoring and integrate these into in vivo probes. The sensors should provide stable (for several weeks) in vivo chemical readout of dopamine (DA) and glutamate (Glu). The sensors will be based on nanocomposite sensing layers incorporating biocompatible metal nanoparticles in combination with enzymatic biorecognition elements encapsulated into thin cell/protein resistant layers (to prevent in vivo biofouling). Different electrochemical sensing schemes will be explored different scanning methods (e.g. square wave potentiometry to identify neurotransmitter-specific peaks, followed by chronoamperometry for millisecond chemical readout), while deep learning methods will be applied to realize multiplexed sensing (i.e. deconvolute individual neurotransmitter release patterns).
Profile
  • You have a Master’s degree in electrical or biomedical engineering, (bio)physics, (bio)chemistry, bioengineering, nano science or nanotechnology;
  • You have distinguished yourself during your bachelor/masters studies;
  • You have a special interest in sensing technologies, in particular in applying physics and engineering in biology and medicine;
  • You are motivated, ambitious, creative and result-oriented;
  • You are able to work independently in an international and multidisciplinary team;
  • You are fluent in English oral and written communication.
Offer

  • We offer a 4-year, full-time doctoral scholarship (pending a positive evaluation before the end of the first year), starting after 1st October 2024.
  • You will have the opportinity to work in a dynamic academic environment on a challenging and advance research topic, to help you acquire research expertise, technical skills and soft skills, to participate in national and international scientific events and network with leading researchers in the neurotechnology field.
  • You will be able to develop your teaching and coaching skills by contributing to our taught programmes.
  • Your normal place of work will be Leuven, Belgium.
Interested?
Vul contactpersonen aan in stap 1 "Context vacature" en hergenereer deze tekst.
You can apply for this job no later than September 30, 2024 via the online application tool


KU Leuven strives for an inclusive, respectful and socially safe environment. We embrace diversity among individuals and groups as an asset. Open dialogue and differences in perspective are essential for an ambitious research and educational environment. In our commitment to equal opportunity, we recognize the consequences of historical inequalities. We do not accept any form of discrimination based on, but not limited to, gender identity and expression, sexual orientation, age, ethnic or national background, skin colour, religious and philosophical diversity, neurodivergence, employment disability, health, or socioeconomic status. For questions about accessibility or support offered, we are happy to assist you at this email address.

Heb je een vraag over de online sollicitatieprocedure? Raadpleeg onze veelgestelde vragen of stuur een e-mail naar solliciteren@kuleuven.be

av_timer
Tewerkstellingspercentage: Voltijds
location_city
Locatie : Leuven
timer
Solliciteren tot en met:
30/09/2024 23:59 CET
bookmarks
Tags: Wetenschappen
New Job Alerts
Deschacht Plastics Belgium NV

Magazijnier-Chauffeur

Hoogstraten

FULL TIME

November 6, 2024

View Job Description
EUROPEAN SOCIETY OF CARDIOLOGY

EU project officer - determined contract

Brussels

FULL TIME & CONTRACT

November 6, 2024

View Job Description
CHEMIUM

Business Support Specialist H/F

Ottignies-Louvain-la-Neuve

FULL TIME

November 6, 2024

View Job Description
Equans

CHAUFFAGISTE DE MAINTENANCE - G1 BRUXELLES

Brussels

FULL TIME

November 6, 2024

View Job Description
Babilou Belgium

Verantwoordelijke (m/v/x) kinderdagverblijf te Vorst

Vorst

FULL TIME

November 6, 2024

View Job Description
Puratos

Internship: HR Business Partner

Groot-Bijgaarden

November 6, 2024

View Job Description
Joris Ide

Certification Engineer ( Panels)

Zwevezele

FULL TIME

November 6, 2024

View Job Description
TRENDY FOODS BELGIUM

DISPATCHER

Bornem

FULL TIME

November 6, 2024

View Job Description
Looking for similar job?
KU Leuven

Joint PhD position: Health Policies for the Implementation of a self management & monitoring app in routine perinatal care

Leuven

FULL TIME

September 12, 2024

View Job Description
KU Leuven

Joint PhD position: Implementation of a self management & monitoring app

Leuven

FULL TIME

September 17, 2024

View Job Description
KU Leuven

Joint PhD position: Predictive models for early childhood obesity

Leuven

FULL TIME

September 16, 2024

View Job Description
VIB

Group Leader Position: AI in Plant Biology

Ghent

FULL TIME & PART TIME

September 22, 2024

View Job Description
KU Leuven

PhD research Position: Development of AI architectures for clinical decision support in glioblastoma

Leuven

FULL TIME

October 22, 2024

View Job Description
VIB

Group Leader Position: AI in Plant Biology

Ghent

FULL TIME & PART TIME

October 23, 2024

View Job Description
See What’s New: KU Leuven Job Opportunities
KU Leuven

PhD position in Genomics of structural heart defects

Leuven

FULL TIME

November 6, 2024

View Job Description
KU Leuven

Optimising Real-Time Multimodal Data Collection for Assistive Technology (AERIALIST DC5)

Brugge

FULL TIME

October 29, 2024

View Job Description
KU Leuven

Postdoctoral project on cancer therapy via nanomedicine, engineered cells and preclinical imaging

Leuven

FULL TIME

October 25, 2024

View Job Description
KU Leuven

PhD research position for preclinical and translational research in sarcoma

Leuven

FULL TIME

October 23, 2024

View Job Description
KU Leuven

PhD research Position: Development of AI architectures for clinical decision support in glioblastoma

Leuven

FULL TIME

October 22, 2024

View Job Description
View More Jobs by KU Leuven
New Job Alerts
Deschacht Plastics Belgium NV

Magazijnier-Chauffeur

Hoogstraten

FULL TIME

November 6, 2024

View Job Description
EUROPEAN SOCIETY OF CARDIOLOGY

EU project officer - determined contract

Brussels

FULL TIME & CONTRACT

November 6, 2024

View Job Description
CHEMIUM

Business Support Specialist H/F

Ottignies-Louvain-la-Neuve

FULL TIME

November 6, 2024

View Job Description
Equans

CHAUFFAGISTE DE MAINTENANCE - G1 BRUXELLES

Brussels

FULL TIME

November 6, 2024

View Job Description
Babilou Belgium

Verantwoordelijke (m/v/x) kinderdagverblijf te Vorst

Vorst

FULL TIME

November 6, 2024

View Job Description
Puratos

Internship: HR Business Partner

Groot-Bijgaarden

November 6, 2024

View Job Description
Joris Ide

Certification Engineer ( Panels)

Zwevezele

FULL TIME

November 6, 2024

View Job Description
TRENDY FOODS BELGIUM

DISPATCHER

Bornem

FULL TIME

November 6, 2024

View Job Description