Oncology Research at Orion is seeking an innovative, talented, and highly motivated team leader to guide a team of researchers and assistants working to identify, validate, and mechanistically characterize novel oncology targets, as well as to support preclinical drug discovery efforts to develop life-changing therapies.
About the position
As the Head of Cancer Genomics, you will lead a team focused on identifying novel cancer vulnerabilities using genetic and molecular data. You will leverage innovative in vitro and in vivo model systems, along with a broad range of functional technologies such as CRISPR, RNAi, and small molecule approaches. This role is ideal for someone who enjoys the translational aspects of converting biology discoveries in cancer research into drug discovery programs and thrives in a team environment. Key Responsibilities include the following:

• Lead a team of assistants and Ph D and non-Ph D level scientists providing scientific and technical guidance.
• Develop and execute strategies for target identification, prioritisation, and validation. Apply genetic, biochemical, and cell biology techniques for detailed mechanistic studies of identified targets.
• Lead the setup and execution of relevant assays and models for in vitro and in vivo screening and efficacy studies.
• Drive the innovation and implementation of new techniques and methodologies to advance research projects.
• Develop action plans, strategies, and go/no-go criteria at each stage of the drug discovery process.
• Interact with internal and external experts, academic groups, and CROs to establish collaborations and support research projects.
• Ensure delivery of a robust pipeline of high-value, high-confidence research projects

You will be based in Turku, Finland, and report to the Director of Oncology Research.
Description of Unit
Orion’s pharmaceutical innovations are created within its R&D organisation. The organisation employs top professionals in the field of drug discovery and development.
There are around 400 professionals working in R&D. Orion R&D has offices in Espoo, Turku and Kuopio in Finland, and in Nottingham in England and in New York, NY, USA.
Cancer Genomics is one of three scientific units in Oncology Research, a part of Orion's R&D Organization. Cancer Genomics Team is focused on the discovery of therapeutic targets and the development of life-changing therapies to build well-being of patients globally.
We Offer

• Opportunity to work with a dynamic team of experts building up Oncology Research at Orion.
• A highly interesting R&D pipeline and enthusiastic working environment with opportunities to use your own strengths to build your competence and career.
• Exciting opportunity to innovate and have an impact on future therapies for patients.
• An excellent working atmosphere based on the appreciation of colleagues, continuous development, and mutual trust. Learn more about Orion as an employer https://www.orion.fi/en/careers/orion-as-an-employer/.

Requirements
A doctoral degree in Cell Biology, Molecular Biology, Biochemistry, or a related field with more than six years of post-doctoral experience in oncology research.
Deep understanding of the mechanisms driving cancer growth, synthetic lethal strategies, and experience in using genomic information and functional genomics data for identifying novel cancer dependencies, along with the integration and utilisation of large-scale multi-omic datasets.
Proficiency in a broad range of biochemical, molecular, and cell biological techniques, including

• Expertise in in vitro and in vivo cancer models and cell proliferation assays.
• Functional genomic techniques, such as RNAi and CRISPR.
• Cell-based assays, including immunofluorescence and high content imaging.
• In vitro high-throughput biochemical screening assays using recombinant proteins.

Good leadership and team management skills and demonstrated ability to drive projects to successful completion.
Candidates with experience in the pharmaceutical or biotechnology industry will be given preference.
Additional Information
If you are the person we are looking for, please submit your cover letter and CV via the link by 27th October 2024.
For more information on the Head of Cancer Genomics position, please contact Anu Moilanen, Director Oncology Research, tel. +358 50 966 7827 the following times: October 22nd, 16-17:00 EEST or Oct 24th 10-11 EEST.
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Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.

Orion Corporation operates in more than 30 countries, where we Orionees, 3600 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.