Heidelberg


Full-time


Clinical Cooperation Unit "Applied Tumor Immunity"

YOUR TASKS

• Design and optimize multi-marker immunohistochemistry and immunofluorescence protocols for tissues
• Oversee tissue processing, embedding, sectioning and staining of human tissue samples
• Validate and troubleshoot existing staining protocols to ensure accuracy and reproducibility
• Design / execute experiments using spatial technologies, e.g. spatial transcriptomics and multiplex immunofluorescence
• Design stain to slide analysis workflows that can drive discovery and translation of spatial biology insights to the clinic
• Perform tissue annotations and image analysis using digital pathology software, e.g. HALO, Qu Path
• Analyze and interpret experimental data and contribute to the development of novel hypotheses
• Design experiments with internal / external partners and coordinate implementation to enable project success
• Supervise technicians and work closely with biologists, clinicians and computational scientists to drive translational and clinical research
• Oversee the seamless operation of the lab, e.g. scheduling, training, supply management and maintenance of the technical infrastructure
• Maintain detailed record keeping and required documentation
• Stay current with advancements in the aforementioned fields and apply new techniques to ongoing projects
• Present research findings at conferences and contribute to the preparation of scientific publications and grant applications

YOUR PROFILE

• A Ph D (or Master with 5 years of industry / research experience) in biology, immunology, biomedical science, biomedical engineering or related field with a strong emphasis on histology and spatial technologies
• Prior experience in cancer research and particularly in the tumor immune environment
• Strong analytical skills and experience with data interpretation in the context of tumor immunology
• Ability to work independently but also within our multidisciplinary research environment
• Strong problem-solving skills, excellent written and verbal communication skills
• Hands-on experience with tissue processing, embedding, sectioning, and histological staining techniques
• Proficiency in spatial technologies such as spatial transcriptomics, multiplex immunofluorescence or similar methods
• Expertise in tissue biomarkers and an understanding of the tumor immune contexture
• Experience with digital pathology software, e.g. HALO, Qu Path
• Knowledge of molecular biology, cell culture, or immunological assays
• Experience in writing, managing and reviewing SOPs
• Experience in general lab management, e.g. purchasing, stock controls, working with field service engineers, routine calibration, quality control, waste management
• Proven track record of research publications in journals and conferences related to the position

WE OFFER

ARE YOU INTERESTED?