Mainz


Vollzeit


HI-TRON Mainz - Personalized Immunotherapies

YOUR TASKS

• Lead the development and optimization of LNP formulation for cell-specific biomolecule delivery, including high-throughput screening of lipid compositions and formulation parameters
• Develop and apply methods for LNP purification and characterization
• Apply in vitro and in vivo models to assess biodistribution, efficiency, toxicity, and cell-specific LNP uptake
• Lead the development of LNP targeting strategies using ligand conjugation, peptides, or antibodies for cell/tissue-specific delivery
• Present research findings internally and externally (national and international conferences) and publish in peer-reviewed scientific journals
• Identify new research directions, develop grant proposals, and contribute to securing external funding

YOUR PROFILE

• Master's degree and Ph D in pharmaceutical sciences, chemistry, bio- or chemical engineering, or related fields
• Extensive experience in LNP formulation methods, including hands-on experience with microfluidic devices, and targeted delivery strategies, including bioconjugation techniques
• Deep knowledge in nanoparticle purification (e.g., size-exclusion chromatography, ultracentrifugation, and dialysis), and characterization (e.g. dynamic light scattering, and Cryo-EM)
• Strong background in relevant in vitro and in vivo models and approaches for evaluating key parameters of nanoparticles, such as efficacy, biodistribution, and toxicity
• Proven publication record in high-impact journals related to biological therapeutics and nanomedicine
• Meticulous, quality-focused, and able to work independently while consistently meeting deadlines with a high degree of accuracy and efficiency
• Strong written and oral communication skills in English with effective interpersonal skills that foster teamwork and collaboration

WE OFFER

ARE YOU INTERESTED?