Ireland Job Openings
National Institute for Bioprocessing Research and Training (NIBRT)
Research Associate
Dublin
CONTRACT
August 12, 2024
Research
Vacancy Summary
This is an exciting, 4-year opportunity for a Research Associate to work on, and influence, a research programme funded through a prestigious SFI Research Professorship award to Professor Mark Smales in the area of enhancing advanced biotherapeutic biological medicines design, manufacturing and activity at NIBRT. There is a growing portfolio of advanced biotherapies, including modalities such as gene therapies, cell therapies and RNA therapeutics as vaccines and therapeutics, for which the manufacturing processes are often low yielding and inefficient. The role will help deliver a work programme to generate a fundamental, transformative and conceptual mechanistic shift in our understanding of the cell expression systems and processes used to produce these advanced biotherapeutics, and apply modern engineering biology approaches to deliver more efficient, predictable, and affordable manufacturing approaches.
Position Available
Research Associate
Location
Dublin, Ireland
Department
Research
Hiring Manager
Professor Mark Smales
Contract Type
4 Year Specific Purpose Contract
Application Date
ASAP
Interview Dates
TBC
Salary & Benefits
Competitive salary and excellent suite of benefits including pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported.
Role Purpose
The postholder will be expected to (1) undertake the work and training programme outlined in the grant proposal ‘Enhancing Advanced Biotherapeutic Design, Manufacturing and Activity: Defining and Leveraging the Biological Rules that Underpin AAV Gene Therapy, IVTm RNA and Protein Biotherapeutic Modality Design and Production’ for the Research Associate, and (2) provide technical and laboratory support for other members of Prof Smales team at NIBRT.
Key Responsibilities
The key responsibilities of the job include:
- To support the general running of the laboratory, preparation of molecular biology reagents, media, samples, routine cell culture and cloning work, and bioreactor runs.
- To undertake appropriate experiments to achieve the goals and milestones as described in the Research Professor- ship SFI funded grant programme “Enhancing Advanced Biotherapeutic Design, Manufacturing and Activity: Defining and Leveraging the Biological Rules that Underpin AAV Gene Therapy, IVTm RNA and Protein Biotherapeutic Modality Design and Production”, specifically those associated to the Research Associate position in WP1 around recombinant AAV production.
- To undertake the mandatory training, reporting, public engagement/outreach activities and any other requirements outlined under the funding agreement for the project.
- Be responsible for maintenance of laboratory records, health and safety records, and inventory around the project.
- To interact with other collaborators at NIBRT and externally, both within Ireland and internationally, coordinating activity across the consortium including the exchange of reagents.
- Regularly report to the PI and supervisors, compile data acquired in a form to allow rapid transformation of documented research results into high quality research papers and/or patent applications.
- Attend and present at training activities and research summits and meetings as outlined in the wider programme.
- Be committed to your own personal career development, including continually updating knowledge and understanding in fields related to the research area.
- Other duties, commensurate with the grading of the job, as assigned from time to time.
Essential Criteria
- A BSc (Hons 2/2 minimum) or preferably an MSc in biotechnology, biochemistry, biochemical engineering, genetics, molecular biology, gene therapy, engineering biology, synthetic biology, RNA sequencing or a relevant discipline.
- Training/experience of working with mammalian cells in culture.
- Experience of molecular biology, plasmid DNA preparation, preparation of media and other
- Training and experience in DNA, m RNA and protein analysis.
Desirable Criteria
- Experience of working with CHO and HEK293 cells in culture.
- Experience of q RT-PCR transcript analysis.
- Knowledge and/or experience of running Ambr® fermentation experiments.
- Knowledge of the wider bioprocessing field.
- Experience of engineering of mammalian cells.
- Previous experience as a research technician in a working laboratory.
Required Skills & Competencies
- Evidence of ability to keep meticulous laboratory records and provide written reports describing work undertaken and the results from this.
- Good basic IT knowledge (for example Microsoft Office).
- Ability to work as part of a team and independently as required.
How To Apply?
To apply for this position please forward your CV and cover letter to careers@nibrt.ie
Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits.
Informal enquiries can be made in confidence by contacting careers@nibrt.ie
NIBRT is an Equal Opportunities Employer.
Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits.
Informal enquiries can be made in confidence by contacting careers@nibrt.ie
NIBRT is an Equal Opportunities Employer.
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