Italy Job Openings

Istituto Italiano di Tecnologia

Fellow senior position Early Retinal Neurodegeneration as Risk Factor, Biomarker and Pharmacological Target of Diabetic Retinopathy

Genoa

November 7, 2024

Fellow senior position Early Retinal Neurodegeneration as Risk Factor, Biomarker and Pharmacological Target of Diabetic Retinopathy
- (2400007X)

Commitment & contract: collaboration contract for one-month (January 2025)
Location: Center for Synaptic Neuroscience and Technology, Genova, Italy
WHO WE ARE
At IIT we work enthusiastically to develop human-centered Science and Technology to tackle some of the most pressing societal challenges of our times and transfer these technologies to the production system and society. Our Genoa headquarter is strictly inter-connected with our 11 centers around Italy and two outer-stations based in the US for a truly interdisciplinary experience.
YOUR TEAM
You will be working in a multicultural and multi-disciplinary group, where biomedical engineers, biologists, physicists, chemists, biotechnologists, and computational scientists collaborate, each with their own expertise, to carry out common research.
The Neuroscience and Smart Materials Research Unit is coordinated by Prof. Fabio Benfenati, who has extensive experience in biomedicine, neurophysiology, and neural interfaces. The research focuses on the neuronal physiopathological mechanisms that lead to diabetic retinopathy.
Despite the evidence that diabetic retinopathy (DR) still remains the first cause of blindness among the working-age population, it lacks a specific preventive treatment. This is due to the fact that early mechanisms leading to the development of DR have been, until recently, unknown. Recent findings have shown that DR is preceded by retinal neurodegeneration focused on retinal ganglion cells. The aim of this project will be to verify whether neurodegeneration could represent a pharmacologic target. A specific therapeutic intervention during this early phase of DR could allow, for the first time, to prevent complications by acting on the initial pathogenetic mechanisms. However, it remains to be clarified whether an early anti-inflammatory or antioxidant therapy (or combination of both) in the course of diabetes is actually able to prevent DR. To this end, the use of molecules of natural origin for their proven tolerability and ability to interact with crucial molecular pathways of inflammation is becoming increasingly interesting. In particular, the proposing group has proven experience in the use of Repron saffron (saffron that naturally has particular concentrations of its constituent molecules such as to provide neuroprotective effects, under patent) as a food supplement for the prevention and mitigation of degeneration of photoreceptors. Retinal dysfunction will be evaluated.
Within the team, your main responsibilities will be:

Contribute to the experiments to test the efficacy of Saffron Repron© in preventing diabetic retinopathy.

This open position is financed by the Ministry of Health/PNRR-Next Generation EU (Project Code: PNRR-MAD-2022-12376008) "Early Retinal Neurodegeneration as Risk Factor, Biomarker and Pharmacological Target of Diabetic Retinopathy" CUP J53C22004130007, admitted to funding by the Ministry of Health for the implementation of Investment 2.1 – Enhancement and strengthening of biomedical research of the NHS – as part of Mission 6 "Health", Component C2 "of the National Recovery and Resilience Plan.
WHAT WOULD MAKE YOU SHINE

A Ph D in Biotechnology, Molecular Biology, Neuroscience or similar
Documented experience in Neurophysiology
A strong publication record
The ability to properly report, organize and publish research data
Good command in spoken and written English

EXTRA AWESOME

Knowledge of retinal physiology
Knowledge and experience in in-vivo retinal electrophysiology
Good communication skills
Strong problem-solving attitude
High motivation to learn
Spirit of innovation and creativity
Good in time and priority management
Ability to work in a challenging and international environment
Ability to work independently and collaboratively in a highly interdisciplinary environment

COMPENSATION & BENEFITS

Competitive salary for international standards
Wide range of staff discounts

WHAT’S IN FOR YOU

An equal, inclusive and multicultural environment ready to welcome you with open arms. Discrimination is a big NO for us!
We like contamination and encourage you to mingle and discover what other people are up to in our labs!
If paperwork is not your piece of cake, we got you! There’s a specialized team working to help you with that, especially during your relocation!
If you are a startupper or a business-minded person, you will find some exceptionally gifted professionals ready to nurture and guide your attitude and aspirations.
If you want your work to have a real impact, in IIT you will find an innovative and stimulating culture that drives our mission to contribute to the improvement and well-being of society!
We stick to our values! Integrity, courage, societal responsibility and inclusivity are the values we believe in! They define us and our actions in our everyday life. They guide us to accomplish IIT mission!

If you feel this tickles your appetite for change, do not hesitate and apply!
Please submit your application using the online form and including a detailed CV and a cover letter (outlining motivation, experience and qualifications).
Application’s deadline: November, 21, 2024
We inform you that the information you provide will be used solely for the purposes of evaluating and selecting professional profiles in order to meet the requirements of Istituto Italiano di Tecnologia.
Your data will be processed by Istituto Italiano di Tecnologia, based in Genoa, Via Morego 30, acting as Data Controller, in compliance with the rules on protection of personal data, including those related to data security.
Please also note that, pursuant to articles 15 et. seq. of European Regulation no. 679/2016 (General Data Protection Regulation), you may exercise your rights at any time by contacting the Data Protection Officer (phone Tel: +39 010 28961 - email: dpo@iit.it ).

Primary Location GENOVA S. MARTINO

Job Fellow

Organization Neuroscience and Smart Materials

Job Posting Nov 7, 2024, 9:11:00 AM

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