Spain Job Openings

Center for Genomic Regulation

Bioinformatician in the group 'Evolutionary Processes Modeling

Barcelona

October 3, 2024

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role

We are looking for a bioinformatician to join the 'Evolutionary Processes Modeling' group. We use computational analysis of sequencing data together with population genetics predictions and statistical modeling to answer questions about mutational processes and selective pressures in cancer tumors. The candidate will analyze tumor sequencing data, develop a computational pipeline and test biological hypotheses.

About the group

Cancer is a genetic disease, subject to population genetics forces like mutation, selection and stochasticity. Our group is particularly interested in how the evolution and survival of cancer cell populations relies on mutation influx as well as in selection inference from observed mutation data. To this end, we develop mathematical and computational approaches to estimate mutation rates and selection. Coding sequences of cancer tumors not only exhibit positively selected mutations that drive cancer (www.nature.com/articles/s41588-019-0572-y), but there also exists a small fraction of genes that the tumor cannot afford to lose (www.nature.com/articles/ng.3987). In addition to genes, cancer driver loci can occur in the non-coding part of the genome (www.nature.com/articles/s41467-017-00100-x). Estimates of the strength of selection in cancer allow for a prioritization of genes and non-coding regions by their disease relevance, with the ultimate goal of promoting therapeutic advances.

We are also interested in mutation rates and selection inference in the context of human genetic variation, including polymorphisms (http://www.nature.com/articles/ng.3831; academic.oup.com/mbe/article-abstract/36/8/1701/5475505) and de novo variants (www.nature.com/articles/s41467-020-17162-z). Here, a particular focus of the group lies on the description of purifying selection in humans and across species, accounting for mutational processes as well as the effects of genetic drift.

The Evolutionary Processes Modeling lab was established in October 2018 and is part of the “Bioinformatics and Genomics” program at the CRG. Further information can be found at https://weghornlab.net/ and at www.crg.eu/en/programmes-groups/weghorn-lab.

Whom would we like to hire?

Professional experience

Must Have

You have experience with computer programming

You have used bioinformatics methods for the purpose of sequencing data analysis

Education and training

You should have a master's degree in bioinformatics, mathematics, physics, computer science or a related discipline

Languages

You are fluent in English

Technical skills

You must be able to program in python

You should have experience with working on a cluster

Competences

You have good communication skills

The Offer – Working Conditions

Contract duration: Technical and scientific activities contract with estimated duration of 11 months.

Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.

Target start date: As soon as possible.

We provide a highly stimulating environment with state-of-the-art infrastructure and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconcile a work and family life of its employees and is offering extended vacation periods and the possibility to benefit from flexible working hours.

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