Spain Job Openings

Center for Genomic Regulation

Postdoc - Gene regulation in Hematopoiesis

Barcelona

August 28, 2024

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role

The Single Cell and Synthetic Genomics of Blood Formation lab (PI: Lars Velten) at CRG Barcelona is looking for a motivated computational or mixed computational – experimental postdoc to use synthetic enhancers, CRISPR screening and computational approaches to unravel the logic of gene regulation in blood stem cell differentiation.

Blood formation is an essential, biomedically highly relevant, and complex process of cellular differentiation. Our group studies adult hematopoiesis using computational biology, single cell genomics (Velten et al., 2017, Beneyto-Calabuig et al., 2023, Scherer et al., biorxiv), and genetic screens (Schraivogel et al., 2020). In the past four years, we have established a research line using fully synthetic DNA constructs to understand how hematopoietic stem cells transform continuous transcription factor gradients into cell state specific gene expression patterns, and to engineer artificial, cell state specific hematopoietic enhancers from scratch (Frömel et al., biorxiv). In our primary hematopoietic stem cell expansion and differentiation system, we screen the cell-state specific activity of 10,000s of synthetic enhancers, alone or in combination with CRISPR perturbations of transcriptional regulators, using bulk and single cell readouts.

In your new role, you would

Develop a project on gene regulation in the blood forming system

Analyze data from synthetic enhancer MPRA screens, single cell MPRA screens and dual MPRA-CRISPR screens

Design experiments using these technologies, and collaborate with an experienced technician to implement these experiments

Interact closely with both wetlab and computational scientists from the group

Serve as senior member of the team and, down the road, co-supervisor of Ph D students or technical staff

Your work would be part of the project “Artificial Intelligence for Synthetic Genomics of Blood”, funded with a prestigious ERC Starting Grant. A 45 seconds video summary of that grant is available online.

About the lab

My interdisciplinary group investigates the biology of hematopoietic stem cells using a combination of single cell genomics, genetic screens, and computational biology. We strive to develop novel genomic and bioinformatic tools to answer longstanding questions in the field. In particular, we cover two main research lines, a) Gene regulation in healthy hematopoiesis) and b) Clonal function in ageing and disease. The lab has been established in January 2020 and currently consists of six members: Two Ph D students, two bridging postdocs, one postdoc, and two senior technicians. We have received funding from the European Commission, the Spanish and German government, the Spanish Association Against Cancer and the European Hematology Association.

Whom would we like to hire?

Professional experience

Must Have

You hold a Ph D in a relevant field (computational biology, genomics, molecular biology, bioinformatics, biotechnology etc.)

You have demonstrated your ability to lead a challenging research project

You have published at least one primary research paper during your Ph D

You have strong experience in the analysis of non-standard genomics data (e.g. Perturb-Seq, CRISPR screens, Nanopore, custom RNA-seq protocols etc)

Experience in both exploratory and formal data analysis

You have strong programming skills in R or python

You embrace data-driven research and are willing to collaborate with computational biologists

Desirable but not required/ Nice to have

You have, in addition to your computational training, training in experimental work (e.g. cell culture, flow cytometry, cloning, library preparation etc.)

A strong foundation in machine learning and statistics

You have experience with deep learning environments such as tensorflow and pytorch

Education and training

A Ph D in a relevant field (biochemistry, biomedicine, molecular biology, genetics, etc.)

Languages

You are proficient in English

Technical skills

Genomics data analysis

R and python

Competences

Success-driven

Strong academic writing skills

Strong communication skills

Ability to work as part of a team

The Offer – Working Conditions

Contract duration: technical and scientific activities contract, estimated 2 years

Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.

Target start date: January 2025 (flexible)

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

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