Finland Job Openings
Helsingin yliopiston
Postdoctoral Researcher on Genome Regulation of Islet Cell Development
Helsinki
September 2, 2024
Our laboratory is located at the Stem Cell and Metabolism Research Program Unit, Faculty of Medicine, University of Helsinki. We also operate a Core Facility service, the Biomedicum Stem Cell Centre (BSCC).
We study the mechanisms behind human pancreas development and function, and how their disruption can lead to diabetes. We have developed stem cell differentiation protocols to generate functional pancreatic islets (Balboa, Nature Biotechnology 2022), and established multiple in vitro and in vivo disease models of diabetes using genome edited stem cells (Balboa, e Life 2018; Ibrahim, Diabetologia 2024). One of our aims is to integrate single-cell and genetic perturbations data to understand the regulatory logic orchestrating pancreatic islet development and disease.
The postdoctoral fellows will work on the generation of state-of-the-art engineered stem cell models to dissect the transcriptional regulation of islet cell development and function (directed differentiation, 3D pancreas models, in vitro and in vivo genome editing, CRISPR screens), and on the analysis and integration of bulk, single-cell and spatial multi-omics methods with human genetics (transcriptomics, epigenomics, metabolomics).
The successful applicants will join an international multidisciplinary team that combines genome engineering in cellular model systems, single cell and functional genomics to understand mechanisms relevant to diabetes treatment. The group is located at the Meilahti medical campus, the largest biomedical campus in Finland with excellent research facilities and networking opportunities. Our research is funded by the Research Council of Finland (Academy), the Novo Nordisk Foundation, the Wellcome Trust Foundation, and the Faculty of Medicine, among others.
- Stem cell culture and differentiation, metabolism, genome editing, gene therapy, animal models
- Functional genomics, single cell omics methods, transcriptomic, epigenetics, diabetes genetics
The salary will be based on the University salary scheme for research and teaching staff. The starting salary will be ca. 3 700 – 4 000 euros/month, depending on the appointee’s qualifications and experience. The salary will guarantee a high quality of life in Helsinki.
The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, unemployment and pension fund, a generous holiday package, sports facilities, and opportunities for professional development: https://www.helsinki.fi/en/about-us/careers.
For 7th time in a row, Finland has been ranked in 2024 as the happiest country in the world according to the annual World Happiness Report and was recently rated as the best country in the world for expat families. For more information about working at the University of Helsinki and living in Finland, please see https://www.helsinki.fi/en/university/working-at-the-university.
Applications should be submitted through the University of Helsinki Recruitment System via the "Apply now" button.
1. A complete CV, including Ph D thesis title and date of defense, previous and current positions, academic distinctions, teaching and committee work
2. A complete list of publications
3. A summary of current research work (half page) and research vision for postdoctoral goals (half page)
The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master's Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of multidisciplinary education in healthcare: https://www.helsinki.fi/en/faculty-of-medicine
#Helsinki Uni Careers
Tieteen voimalla voidaan muuttaa maailmaa. Olemme yksi maailman parhaista tutkimusyliopistoista – yli 30 000 opiskelijan ja 8 000 työntekijän kansainvälinen tieteen, tutkimuksen, oppimisen ja rohkean ajattelun yhteisö.
Meidät tunnetaan monitieteisyydestä. Uskomme tieteidenvälisen tutkimuksen ja rajoja rikkovan yhteistyön voimaan löytää ratkaisuja ja luoda toivoa paremman ja kestävämmän tulevaisuuden puolesta.
Meitä yhdistävät arvomme totuus, sivistys, vapaus ja yhteisöllisyys, sekä halu tehdä merkityksellisiä töitä.
Tule mukaan: tee työtä tulevaisuudelle – maailman parhaaksi.
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