IRCCS San Raffaele Scientific Institute in Milan, Italy, is looking for a Lab Technician/Research Assistant to join the Process Development Lab (PDL), led by Marina Radrizzani at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) (https://research.hsr.it/en/institutes/san-raffaele-telethon-institute-for-gene-therapy/process-development-lab.html), to work in projects focused on genetic engineering of T lymphocytes and hematopoietic stem cells (HSC).

SR-Tiget was created in 1996 as a joint-venture between Fondazione Telethon and Ospedale San Raffaele (OSR), with the mission to perform cutting edge research on gene and cell therapy and to translate its results into therapeutic advances for genetic diseases. The Institute is located within the OSR campus, which includes a large multi-disciplinary research hospital, a biomedical research center, a university and also hosts several biotechnologies companies. Over the years, SR-Tiget has given a pioneering contribution to the gene and cell therapy field with relevant discoveries in vector design, gene transfer and gene editing strategies, stem cell biology, identity and mechanism of action of regulatory cells in immune responses and innate immune cells in cancer. SR-Tiget has also established the resources and framework for translating these advances into novel experimental therapies and has implemented several successful gene therapy clinical trials, which have already treated >120 patients and led to the filing and approval of 2 novel advanced therapy medicines.

Main activities:
isolation, culture and genetic modification of T lymphocytes and HSC (lentiviral vector transduction, gene editing)
process scale-up and standardization
cell-based assays, molecular assays, flow cytometry analyses
preparation of standard lab procedures and protocols
general lab support

Who we are looking for:
Bachelor or Master Degree (Biomedical Laboratory Technician, Biology, Biotechnology or equivalent), Ph D as a plus
strong lab wet experience
high motivation to work in the field of Advanced Therapy Medicinal Products (ATMP)
high accuracy, reliability, precision
friendly, collaborative, pro-active mindset
good oral and written English
experience in Good Manufacturing Practices, automated cell manipulation systems and/or ATMP as a plus

Work details:
Type of contract: to be defined, depending on qualification and experience
Place of work: IRCCS San Raffaele Hospital, Via Olgettina, number 60 - Milan (Italy)

At San Raffaele Scientific Institute, a world-renowned center of excellence for clinical and scientific activities, we believe that considering diversity and promoting an open and inclusive environment is crucial to our success. We are committed to ensure that equal employment opportunities are provided and based on merit without regard to age, religion, sex, disability, medical condition, sexual orientation, cultural and social backgrounds, gender identity or expression, national or ethnic origin, or any other legally recognized status entitled to protection under applicable laws. We offer attractive conditions and rewards appropriate to an internationally competitive research organization.