Belgium Job Openings
KU Leuven
Postdoctoral project on cancer therapy via nanomedicine, engineered cells and preclinical imaging
Leuven
FULL TIME
October 25, 2024
Postdoctoral project on cancer therapy via nanomedicine, engineered cells and preclinical imaging
(ref. BAP-2024-693)Laatst aangepast: 25/10/24
The field of nanomedicine is receiving increasing attention and has enormous potential for a plethora of pathological conditions, including cancer. One of the main advantages of nanomaterials is the ability to combine multiple modalities in one platform, allowing the nanomaterials to be used simultaneously for diagnostic and therapeutic applications and to use multiple therapeutic options simultaneously. The main bottlenecks hindering the full use of nanomaterials for biomedical purposes is the need for a higher level of selectivity in terms of targeted delivery of the nanomaterials to the target cells, along with the development of new, alternative therapeutic options. These topics are central to the research group. To answer these questions, multidisciplinary research is highly regarded, in which we make extensive use of non-invasive imaging (optical imaging and soon magnetic particle imaging) to investigate the biodistribution and functionality of the nanoformulations.
Responsibilities
- Design, development and characterization of nanoformulations with genetic cargo (m RNA, si RNA, p DNA).
- The culture, evaluation and validation of engineered cell types (CAR-NK and CAR-T).
- The applicant will work on synthesis of nanoformulations. Microfluidic systems (e.g. Ignite system from Precision Nanomedicine) are available in-house to assist.
- The applicant will work on biodistribution and targeted delivery of either the engineered cells or nanoformulations using in vitro (cell culture) and in vivo (mouse models) systems.
- The applicant will propose and design novel targets and/or methods for improving targeted delivery of their therapeutic agents
- The applicant will contribute to teaching the techniques to Ph D students and follow-up on different students.
Profile
- A Ph D (recently completed) linked to biology, medical sciences, pharmaceutical sciences or the like.
- The applicant has experience in cell culture and animal handling and is certified to perform animal experiments.
- Experience with synthesis and characterization of solid lipid nanoparticles, poly(beta-amino esters) and/or chitosan nanoparticles for si RNA, m RNA or p DNA encapsulation is a plus.
- Experience with generating and evaluating CAR-T or CAR-NK cells is a plus.
- Experience with performing in vitro and in vivo tests related to toxicity, encapsulation efficacy and therapeutic efficacy of loaded nanoparticles is a plus
- Any experience with biomimetics for encapsulation of nanocomplexes with biological membranes is a plus
- Any experience with preclinical studies (biodistribution, therapeutic efficacy) is a plus.
- International applicants are a plus, but not a requirement.
- Applicants must be enthusiastic, dynamic, reliable and accurate, willing to incorporate previously learned techniques into new approaches.
- The applicant is a good team player, who likes to be closely supervised and who can also work independently.
- Must have a great sense of responsibility and good organizational skills.
- Applicants must be able to communicate well in English.
Offer
Interested?
location_city Locatie : Leuven
timer Solliciteren tot en met:
15/11/2024 23:59 CET
bookmarks Tags: Beeldvorming en Pathologie, Oncologie, Bio-ingenieurswetenschappen, Cellulaire en Moleculaire Geneeskunde
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