Luxembourg Job Openings
Luxembourg Institute of Health
PhD student in Cancer Metabolism
CONTRACT
September 3, 2024
During the last two decades, the importance of metabolism to support cancer onset and progression has gained increasing attention. Among the various nutrients that support cancer cell metabolism, serine has emerged as a very important one. Serine is not only an important precursor for anabolic metabolism (i.e. nucleotide synthesis) but also supports growth-independent processes that drive metastasis. One key element is the excess catabolism of serine to formate resulting in a phenomenon that we named formate overflow.
In recent years, we have demonstrated that formate promotes cancer cell invasion and metastasis. We know today that formate concentrations within the tumor microenvironment are often increased providing a pro-metastatic environment. Formate can impact cancer progression by auto- and paracrine effects. However, the mechanistic details of those effects remain largely unknown so far. To that end, this new project will focus on the identification of mechanisms relaying the oncogenic effect of formate.
The experimental work will rely on different in vivo (mouse) models in combination with state-of-the-art stable isotope-assisted metabolomics techniques (both in vitro and in vivo). Analyses of a patient tissue collection is also foreseen.
The project is funded via a Televie (PDR) grant and will be in close collaboration with a partner from Belgium who has developed a genetically engineered mouse model of lung cancer.
The successful candidate will be embedded in a state-of-the-art laboratory at the Department of Cancer Research (~ 90 members). The Meiser lab currently consists of 3 Ph D students, one lab manager, one technician, four Postdoctoral fellows and an adjunct in-house Mass Spectrometry platform.
Relevant publications :
https://scholar.google.de/citations?hl=de&pli=1&user=1Kt1j Dk AAAAJ
Key Skills, Experience and Qualifications
- Successful Msc in the area of biology;
- Knowledge and keen interest in mammalian metabolism;
- Hands-on experience in experimental lab work (cytometry, Western Blot etc);
- Experience with 3D models may be of advantage;
- Open minded, self-driven and curious person, willing to work in a collaborative team.
Envisaged start date is February 2025.
For any further information, please contact Dr. Johannes Meiser: johannes.meiser@lih.lu
Gender Equality
The LIH is an equal opportunities employer. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff. The LIH is attentive to gender representation among its leadership staff and aims to eliminate obstacles to the recruitment and promotion of female leaders and their career development.
In Short...
- Contract type : Fixed-term contract (CDD)
- Contract duration : 48 months
- Work hours : 40h/week
- Location : rue Nicolas-Ernest Barblé 6 - 1210 Luxembourg
- Start date : ASAP
- Ref : MC/Ph D0924/JM/CMG
How to apply
Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website.Please apply ONLINE formally through this web page.
Applications by email will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
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