Norway Job Openings
Oslo universitetssykehus
PhD student
FULL TIME
October 23, 2024
Ph D studentInstitute for Cancer Research, Dept. of Radiation Biology
Apply for position
(in new tab)
About the position
Oslo University Hospital
Oslo University Hospital (OUH) is a highly specialized hospital in charge of extensive regional and local hospital assignments, and is accredited as a Comprehensive Cancer Center (CCC). As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a responsibility for a number of national and multi-regional assignments, and has several national centers of competence. OUH is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel. The hospital hosts one of the largest radiotherapy centers world-wide, with about 6000 new patients receiving state-of-the-art radiotherapy each year. The center is located at the Radium Hospital in close vicinity to the Institute for Cancer Research. A Proton Therapy center is under construction at the same location. The Proton Therapy center will open in 2024-2025 and includes a cyclotron, 2 treatment rooms for cancer patients and a facility for preclinical research. We plan to include about 75% of all patients treated at the proton center in clinical studies. The preclinical proton facility will consist of a treatment room with gantry, a room for stalling and work with small animals, a preclinical MR-scanner and laboratory for cell work and will offer a unique setting for proton therapy research.
Institute for Cancer Research
The Institute for Cancer Research (ICR) organized as a part of the Division of Cancer Medicine at OUH, conducts cutting edge cancer research ranging from basic cancer biology to translational and clinical research. It is the leading cancer research institute in Norway and has a strong international standing. ICR is organized in 6 research departments, currently with altogether 25 research groups, approx. 390 employees and an annual output of approx. 230 peer reviewed publications. Particularly strong research areas are molecular genetics, cell biology, cancer progression and metastasis biology, biomarker discovery and development, radiation biology, tumour immunology/immunotherapy and systems biology. The groups conduct particularly strong translational research within breast cancer, colorectal cancer, lung cancer, lymphomas, sarcomas, melanoma, gynaecologic cancers and prostate cancer. ICR also hosts a department for core facilities including NGS/genomics platforms, bioinformatics, flow- and mass cytometry, pre-clinical imaging scanner (incl. animal MRI) and X-ray machine, and electron-, confocal- and high-resolution microscopy. In collaboration with The University of Oslo, ICR is in the leadership of a Center of Excellence (Can Cell), a K.G. Jebsen Center for B cell malignancies, a Centre for Advanced Cell Therapy (ACT) and a new Norwegian Centre for Clinical Cancer Research (MATRIX), as well as other large nation-wide collaborative projects and EU funded projects. For further information see institute; ous-research.
Oslo University Hospital is a workplace with great diversity. We believe that this is absolutely crucial to solving the tasks required of us. We therefore want this diversity to be reflected among the applicants for our positions and encourage everyone to apply regardless of who you are and what background you have.
Institute for Cancer Research
The Institute for Cancer Research (ICR) organized as a part of the Division of Cancer Medicine at OUH, conducts cutting edge cancer research ranging from basic cancer biology to translational and clinical research. It is the leading cancer research institute in Norway and has a strong international standing. ICR is organized in 6 research departments, currently with altogether 25 research groups, approx. 390 employees and an annual output of approx. 230 peer reviewed publications. Particularly strong research areas are molecular genetics, cell biology, cancer progression and metastasis biology, biomarker discovery and development, radiation biology, tumour immunology/immunotherapy and systems biology. The groups conduct particularly strong translational research within breast cancer, colorectal cancer, lung cancer, lymphomas, sarcomas, melanoma, gynaecologic cancers and prostate cancer. ICR also hosts a department for core facilities including NGS/genomics platforms, bioinformatics, flow- and mass cytometry, pre-clinical imaging scanner (incl. animal MRI) and X-ray machine, and electron-, confocal- and high-resolution microscopy. In collaboration with The University of Oslo, ICR is in the leadership of a Center of Excellence (Can Cell), a K.G. Jebsen Center for B cell malignancies, a Centre for Advanced Cell Therapy (ACT) and a new Norwegian Centre for Clinical Cancer Research (MATRIX), as well as other large nation-wide collaborative projects and EU funded projects. For further information see institute; ous-research.
Oslo University Hospital is a workplace with great diversity. We believe that this is absolutely crucial to solving the tasks required of us. We therefore want this diversity to be reflected among the applicants for our positions and encourage everyone to apply regardless of who you are and what background you have.
Key information
Application deadline:
01.11.2024
Employer:
Oslo universitetssykehus HF
Title:
Ph D student
Positions:
1
Full-time/part-time:
Full-time
Employment type:
Contract
Percentage of full-time:
100
Webcruiter ID:
4875351390
Social sharing :
Share on x
Share on Linked In
Share on Facebook
Share by email
Department of Radiation Biology
The mission of Department of Radiation Biology (DRB) is to improve the outcome of cancer treatment by radiation-based strategies. DRB is an interdisciplinary team of approximately 60 employees consisting of physicists, molecular biologists, biochemists, pharmacists, medical doctors and engineers, organized in 5 research groups and 4 project groups. The research at the department is focused on the biological responses to ionizing and non-ionizing radiation. The vision is to develop a biological understanding of the radiation responses on the molecular, cellular and physiological level, and to utilize this knowledge to design new strategies for the treatment of cancer. Our research strategy involves basic, translational and clinical radiobiological research as well as pursuing innovations for improved radioterapeutic outcome. For further information, see radiationbiology
The Research Group on Photochemical Internalization
Photochemical internalisation (PCI) is a novel technology for improving the transfer of macromolecules into the cytosol of cells. This is executed through photochemical targeting of endocytic vesicles, leading to release of the contents of these vesicles into the cytosol. The group's main focus is to develop PCI for therapeutic purposes. The PCI group has three main focuses:
Job description
We are seeking a dedicated, creative and enthusiastic candidate for a Ph D research fellow at our Department of Radiation Biology. The position is funded by internal resources and is available for three years.The position will be associated with Anette Weyergang's project group were they are developing new drugs (recombinant targeting toxins) for PCI-delivery. The project will include molecular design of targeted toxins following recombinant production, purification and testing in relevant models. The project group has generated supportive in vitro and in vivo data on one targeted toxin for the treatment of head and neck cancer (HNSCC) and will with this project explore other variants of the concept. The project also harbors evaluation of the targeted toxins in combination with PCI and immunotherapy. Anette Weyergang will supervise the project.
The project will involve molecular cloning and small scale production of 2-5 targeted toxins to identify candidates to proceed. In vitro testing of the targeted toxins in combination with PCI will be done in several cancer models both in vitro and in vivo. Methods will include cloning, protein purification (liquid chromatography) monolayer culturing, cellular viability assays, evaluation of protein signal transduction (Western blotting, fluorescence microscopy, flow cytometry), PCI, evaluation of anticancer efficacy in mice (tumour growth delay, IHC, IVIS, MRI).
The Research Group on Photochemical Internalization
Photochemical internalisation (PCI) is a novel technology for improving the transfer of macromolecules into the cytosol of cells. This is executed through photochemical targeting of endocytic vesicles, leading to release of the contents of these vesicles into the cytosol. The group's main focus is to develop PCI for therapeutic purposes. The PCI group has three main focuses:
- Revealing the mechanisms regulating the treatment outcome
- Developing novel drugs for PCI delivery (recombinant proteins)
- Study immunological aspects on the treatment outcome.
Job description
We are seeking a dedicated, creative and enthusiastic candidate for a Ph D research fellow at our Department of Radiation Biology. The position is funded by internal resources and is available for three years.The position will be associated with Anette Weyergang's project group were they are developing new drugs (recombinant targeting toxins) for PCI-delivery. The project will include molecular design of targeted toxins following recombinant production, purification and testing in relevant models. The project group has generated supportive in vitro and in vivo data on one targeted toxin for the treatment of head and neck cancer (HNSCC) and will with this project explore other variants of the concept. The project also harbors evaluation of the targeted toxins in combination with PCI and immunotherapy. Anette Weyergang will supervise the project.
The project will involve molecular cloning and small scale production of 2-5 targeted toxins to identify candidates to proceed. In vitro testing of the targeted toxins in combination with PCI will be done in several cancer models both in vitro and in vivo. Methods will include cloning, protein purification (liquid chromatography) monolayer culturing, cellular viability assays, evaluation of protein signal transduction (Western blotting, fluorescence microscopy, flow cytometry), PCI, evaluation of anticancer efficacy in mice (tumour growth delay, IHC, IVIS, MRI).
- The Ph D candidate will be expected to conduct research in Photomedicine leading to a Ph D degree
- Complete the doctoral education up to an obtained doctoral degree
-
Appointment to a Ph D position requires that you are admitted to the Ph D program at the University of Oslo, Department of Pharmacy, within three months of employment, and that you participate in an organized Ph D program during the employment period.
- Attend international conferences, workshops and courses.
Required selection criteria/ Qualifications:
- Master's degree in molecular cell biology, pharmacy or biomedical sciences
-
Approved course of laboratory Animal Sciences for scientists. FELASA Cat. C
-
Experience with automatized liquid chromatography systems
-
Experience with standard in vitro methods in cancer research
-
Experience with photomedicine
-
Experience with laboratory mice
-
Fluent in oral and written English (Norwegian is an advantage).
- Digital competence is an advantage.
Personal qualities
- Strong teamwork skills
- Analytical and Critical Thinking
- Ability to work independently and take initiatives
-
Entrepreneurial mind-set
We offer
-
Exciting and stimulating tasks in a strong international academic environment
an open and inclusive work environment with dedicated colleagues - The position is included in the Norwegian Health Assurance and Retirement Pension Schemes, and the salary will be within the official range at OUH for Ph D candidates.
- An enthusiastic work environment with broad expertise and high professional level
- Access to high quality instrumentation and services from the Core Facility Department and other in-house instrumentation, such as a preclinical research facility, MRI and X-ray sources for in vitro and in vivo studies, hypoxia-chamber, IVIS, Seahorse (see also corefacilities).
- For additional information please contact Project leader dr. Anette Weyergang, Mobile +47- 40204557, postdoc dr. Sergio Miguel Castaneda Zegarra, Mobile + 47 92336484 or senior scientist, prof. em. Kristian Berg, Mobile +47 40873549.
- CV and certificates
- One page summary describing how you meet the required selection criteria listed above
- Transcripts and diplomas for bachelor's and master's degrees.
- Diploma confirming approved course of laboratory Animal Sciences for scientist FELASA Cat. C
-
Recommendation letters may be included, but not a requirement
Name and contact information of three referee
-
Address:
Open directions
(in new tab)
Contacts
Anette Weyergang
Seniorforsker
Phone:
+4740204557
Sergio Miguel Castaneda Zegarra
Postdoc
Phone:
+4792336484
Kristian Berg
Senior scientist, prof. em.
Phone:
+4740873549
About the employer
Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.
New Job Alerts
Sobi
Associate Director Patient Access Nordic Baltics
Oslo
FULL TIME
November 20, 2024
View Job Description
BW
Junior Marine Superintendent BW LNG - Temporary position
Oslo
FULL TIME
November 19, 2024
View Job Description
Coor
Servicemedarbeider Operation Center
Hammerfest
FULL TIME
November 19, 2024
View Job Description
Euronext
VIE Diversity and Inclusion project officer
Oslo
FULL TIME
November 19, 2024
View Job Description
Looking for similar job?
Oslo universitetssykehus
PhD Student Position Available: Investigating Radiobiological Mechanisms of Cellular Response Induced by TAT
Oslo
FULL TIME & PART TIME
August 14, 2024
View Job Description
JACOBS DOUWE EGBERTS
Studentmedarbeider - Marketing (Friele)
Bergen
PART TIME
August 29, 2024
View Job Description
See What’s New: Oslo universitetssykehus Job Opportunities
Oslo universitetssykehus
Laboratory engineer for organoid research
Oslo
FULL TIME
November 19, 2024
View Job Description
Oslo universitetssykehus
Intensive Care Nurse for assignment in Malawi Department for Global Health
Oslo
FULL TIME & PART TIME
November 15, 2024
View Job Description
Oslo universitetssykehus
Senior Consultant combined with Associate Professor II/Professor II
Oslo
FULL TIME
November 15, 2024
View Job Description
Oslo universitetssykehus
Nurse with neurosurgical experience
Oslo
FULL TIME & PART TIME
November 14, 2024
View Job Description
Oslo universitetssykehus
Researcher
Oslo
FULL TIME & PART TIME
November 7, 2024
View Job DescriptionNew Job Alerts
Sobi
Associate Director Patient Access Nordic Baltics
Oslo
FULL TIME
November 20, 2024
View Job Description
BW
Junior Marine Superintendent BW LNG - Temporary position
Oslo
FULL TIME
November 19, 2024
View Job Description
Coor
Servicemedarbeider Operation Center
Hammerfest
FULL TIME
November 19, 2024
View Job Description
Euronext
VIE Diversity and Inclusion project officer
Oslo
FULL TIME
November 19, 2024
View Job Description