Norway Job Openings

Universitetet i Bergen

PhD Research Fellows in MSCA doctoral training network about targeting RNA with small molecules

Bergen

FULL TIME

August 15, 2024

Ph D positions - targeting RNA with small molecules (Target RNA)

There are vacancies for Ph D-positions in a doctoral training network focusing on targeting RNA with small molecules (Target RNA) in the context of antimicrobial drug discovery.
These are the hosts (place of employment for the positions):
1 Ph D position Astra Zeneca, Sweden
3 Ph D positions Technical University of Denmark, Denmark
2 Ph D positions Goethe University Frankfurt, Germany
1 Ph D position Italian Institute of Technology/University of Bologna, Italy
1 Ph D position Mannheim University of Applied Sciences, Germany
1 Ph D position Department of Chemistry, University of Basel, Switzerland
1 Ph D position University Côte d’Azur France
2 Ph D positions Department of Biomedicine, University of Bergen, Norway
2 Ph D positions Department of Chemistry, University of Bergen, Norway
1 Ph D position Uppsala University, Sweden
All positions with the exception of the one at Uppsala University, Sweden, are full-time, for a fixed-term period of 3 years. The position at Uppsala University is for a period of 4 years. The positions are funded by the EU Horizon through the Marie Skłodowska-Curie Action (MSCA) for doctoral training networks.
Eligibility rules apply for Ph D positions MSCA doctoral training networks. Mobility rules and doctoral candidate rules apply. All applications must be submitted through the Jobbnorge portal. More information about the rules, how to apply and the Jobbnorge portalcan be found here: How to apply for Doctoral Candidate positions in Target RNA | Target RNA | Ui B.

About the project:

We invite applications for 15 three-year Ph D fellowships open to doctoral students recruited internationally. The projects are in fields spanning from molecular microbiology, over molecular and structural biology (using NMR, X-ray crystallography, and cryogenic EM), and computational, organic and medicinal chemistry to assay development, fragment and high-throughput screening.
In recent years it became increasingly evident that RNAs constitute promising macromolecular drug targets for small molecule drugs. By targeting upstream RNA, current undruggable protein-mediated pathways could be effectively modulated thereby opening for innovative therapies that may redefine the treatment strategies for a range of conditions.
The Target RNA doctoral training network brings together expertise and methods from molecular biology, structural biology, biophysics, computational chemistry, synthetic and medicinal chemistry, and microbiology, all the way up to in vivo models to discover new small molecule RNA ligands for selected targets and to characterize the effects of these RN A ligands on microbes and the microbiome. More information about the research programme can be found here: What is Target RNA about | Target RNA | Ui B.
The network will train the doctoral candidates (DCs) with cutting-edge interdisciplinary skills in the discovery and characterization of RNA ligands and the translation of these discoveries into innovations. Thus, Target RNA will deliver a cohort of scientists with an interdisciplinary mind and skill set who are keen and able to push RNA-targeted drug discovery forward. Furthermore, Target RNA will train the DCs also more broadly within structural biology, medicinal chemistry, microbiology and drug discovery, in addition to equipping them with transferable skills like FAIR data principles, and responsible development and sustainable implementation of new innovations. More information about the training program can be found here: Training program | Target RNA | Ui B.
The host institutions are located in Bergen/Norway, Copenhagen/Denmark, Nice/France, Frankfurt/Germany, Mannheim/Germany, Uppsala/Sweden, Mölndal/Sweden, Genoa/Italy, Basel/Switzerland, and Nijmegen/The Netherlands.
More information about the different hosts can be found here: Consortium members | Target RNA | Ui B.

Qualifications and personal qualities:

Information about the qualifications and personal qualities can be found for each Ph D position. An overview of the different doctoral candidate (DC) positions can be found here: 15 Ph D Positions in a MSCA doctoral training network about targeting RNA with small molecules (Target RNA) | Target RNA | Ui B.

Host Astra Zeneca, Sweden:
DC 1: AI-guided design of pre Q1-II and SAM-III riboswitch ligands | Target RNA | Ui B
Research field: Computational Chemistry, Molecular Simulation, Generative Drug Design
Host Technical University of Denmark, Denmark:
DC 2: Fragment-based ligand discovery for the pre Q1-II and SAM-III riboswitches | Target RNA | Ui B
Research field: Fragment-based ligand discovery, organic chemistry
Host Technical University of Denmark, Denmark:
DC 3: Discovery of recruiters of bacterial endoribonucleases | Target RNA | Ui B
Research field: assay development, HTS, organic chemical synthesis, protein expression
Host Technical University of Denmark, Denmark:
DC 4: Hit discovery and structural studies of riboswitch-ligand complexes using NMR and X-ray crystallography | Target RNA | Ui B
Research field: Structural biology, NMR spectroscopy, X-Ray crystallography
Host Goethe University Frankfurt, Germany:
DC 5: Targeting RNA to reshape the gut microbiome | Target RNA | Ui B
Research field: Molecular microbiology, bacterial physiology
Host University Hospital Frankfurt, Germany:
DC 6: Characterization of riboswitch-ligand interactions using NMR spectroscopy and other biophysical methods | Target RNA | Ui B
Research field: NMR of RNA-ligand complexes
Host Italian Institute of Technology/University of Bologna, Italy:
DC 7: Design and synthesis of compounds targeting the group II intron of Enterobacteriales and Candida | Target RNA | Ui B
Research field: Molecular Modeling and Simulations, Computer-Aided Drug Design
Host Mannheim University of Applied Sciences, Germany:
DC 8: Mode of action studies | Target RNA | Ui B
Research field: Molecular microbiology, bacterial physiology
Host Department of Chemistry, University of Basel, Switzerland
DC 10: Lead finding and structural characterization of the 5’-UTR of omp A of A. baumannii using fragment screening and application of paramagnetic NMR restraints | Target RNA | Ui B
Research field: (paramagnetic) NMR, organic synthesis, RNA, structure determination, machine learning, fragment based screening
Host University Côte d’Azur France:
DC 11: Design, synthesis and biological evaluation of RNA ligands targeting the SAM-I/IV riboswitch | Target RNA | Ui B
Research field: Synthetic small molecules for targeting riboswitch RNA
Host Department of Biomedicine, University of Bergen, Norway:
DC 12: Characterization of RNA-ligand interactions using X-ray crystallography and other biophysical methods | Target RNA | Ui B
Research field: structural biology, biophysics
Host Department of Biomedicine, University of Bergen, Norway:
DC 13: Virtual screening and design of riboswitch ligands | Target RNA | Ui B
Research field: molecular modelling, chemoinformatics, computational chemistry
Host Department of Chemistry, University of Bergen, Norway:
DC 14: Design and synthesis of ligands for the FMN riboswitch and the 5’-UTR of omp A | Target RNA | Ui B
Research field: organic synthesis, medicinal chemistry
Host Department of Chemistry, University of Bergen, Norway:
DC15: Establishing a toolbox of warheads for covalent targeting of RNA | Target RNA | Ui B
Research field: organic synthesis, medicinal chemistry
Host Uppsala University, Sweden:
DC 16: Structural characterization of group II introns from Enterobacterales and Candida species and the 5’UTR of omp A bound to inhibitors using cryo-EM | Target RNA | Ui B
Research field: RNA cryo EM, structural biology, RNA biochemistry

Special requirements for the position:

More information on the special requirements for the different Ph D positions can be found here: Doctoral candidates | Target RNA | Ui B. Click on the project title to read the detailed project description and the specific requirements/qualifications for the different DC positions.
Eligibility rules apply for Ph D positions MSCA doctoral training networks. Mobility rules and doctoral candidate rules apply. More information about the rules can be found here: How to apply for Doctoral Candidate positions in Target RNA | Target RNA | Ui B.

We can offer:

The description of the offer, salary and social security can be found for each Ph D position (depending on the host institution) here: Doctoral candidates | Target RNA | Ui B.

Your application must include:

Motivation letter: In Jobbnorge, use the "Application text" field for your motivation letter. No seperate attachement is necessary. The letter must clearly state for which position(s) you apply for. Further, you need to detail how you fulfill the reqirements for all DC position(s) you apply for. (You can apply for up to 3 positions, see instructions here How to apply for Doctoral Candidate positions in Target RNA | Target RNA | Ui B).
CV: In the "Jobb Norge-CV form": Only fill in your 1) personal details, 2) short information about your degrees (in the field "Education / academic qualifications") and 3) recent relevant work experience (in the field "Work experience").
In addition, attach a full CV.
References: In the "Jobb Norge-CV form", under "References": List the names of at least two references with the correct contact information and a work E-Mail address.
Signed mobility declaration: In the “How to apply page” read details about the mobility rule here: How to apply for Doctoral Candidate positions in Target RNA | Target RNA | Ui B.
Transcripts of diplomas in English must be uploaded in Jobbnorge.
If you have not yet completed your master's degree, you can apply provided completion of the final master exam before 01.11.2024. Please submit a statement from your institution confirming the expected date of award of your master's degree.
It is a condition of employment that the master's degree has been awarded (documentation must be provided).

General information:

For further details about the position, see the contact information stated for each position here: Doctoral candidates | Target RNA | Ui B.
For HR related questions contact the host institutions for the position you are applying. List of host institutions can be found here: Consortium members | Target RNA | Ui B.
This MSCA doctoral network has a gender equality plan where gender balance among employees is therefore a goal. We encourage women to apply. If multiple applicants have approximately equivalent qualifications, the rules pertaining to moderate gender quotas shall apply. It is also a goal to recruit people with immigrant backgrounds. People with immigrant backgrounds and people with disabilities are encouraged to apply for the position.
Information about applicants may be made public even if the applicant has asked not to be named on the list of persons who have applied. The applicant must be notified if the request to be omitted is not met.
Further information about the employment process can be found here.

About MSCA Doctoral Networks

The MSCA Doctoral Networks aim to train creative, entrepreneurial, innovative and resilient doctoral candidates, able to face current and future challenges and to convert knowledge and ideas into products and services for economic and social benefit. The MSCA Doctoral Networks raise the attractiveness and excellence of doctoral training in Europe.

Read More about the MSCA Doctoral Networks.

Questions about the position

Anne Mette Søviknes
Project Assistant
anne.soviknes@uib.no

Deadline
15th September 2024

Employer
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