Netherlands Job Openings

Genmab
Intern, Discovery Preparation and Humanization, Antibody Discovery
Utrecht
FULL TIME
October 31, 2024
Within the Discovery Preparation & Humanization team we are offering an internship or graduation project for an enthusiastic MSc student. The candidate will join our team in Utrecht for 7–9 months to conduct scientific research on Genmab's state-of-the-art antibody products and formats and therefore contribute to improving the lives of cancer patients!
Project
In this internship, the focus will be on producing and characterizing oligomeric protein targets. Specifically, the intern will work with engineered protein targets that exist in specific oligomeric states, helping to dissect the impact of these states on antibody binding affinity and behavior using biophysical methods including Surface Plasmon Resonance (SPR) and Isothermal Titration Calorimetry (ITC). The project will be carried out in close collaboration with the Functional Characterization & Bioassays team in the CMC department, providing the intern with hands-on experience in protein design, production, and biophysical characterization.
By developing oligomeric protein targets and benchmarking their in vitro behavior, you will contribute to a better understanding of how the oligomeric state of a target influences antibody binding. This knowledge is expected to improve the screening and characterization of therapeutic antibodies and enable more efficient mapping of antibody binding characteristics.
Responsibilities
- You design proteins that constitutively exist in a certain oligomeric state using protein engineering techniques and you support successful production and purification of these constructs.
- You develop binding assays and perform affinity measurements using SPR and ITC.
- You critically assess the quality and outcome of binding assays and provide the team with detailed molecular hypotheses underpinning the observed behavior.
- You communicate results clearly to the rest of the team or department.
- You work in the lab in an organized manner and strive to consistently generate good results.
- You document results in an organized and concise manner in the Electronic Lab Notebook (ELN).
Requirements
- You are currently connected to a Dutch university and pursuing a Master's degree in a relevant area, e.g. biomedical sciences or biomedical engineering, molecular biology, life sciences, immunology, or similar.
- Knowledge and understanding of protein engineering is a pre.
- Knowledge and understanding of biophysical techniques such as ITC, SPR and BLI is a pre.
- Ability to work successfully in a fast-paced environment in collaboration with a diverse group of scientists and other stakeholders.
- Ability to be proactive, enthusiastic and goal oriented.
- Strong communication skills in English, both oral and written.
About You
- You are passionate about our purpose and genuinely care about our mission to transform the lives of patients through innovative cancer treatment
- You bring rigor and excellence to all that you do. You are a fierce believer in our rooted-in-science approach to problem-solving
- You are a generous collaborator who can work in teams with diverse backgrounds
- You are determined to do and be your best and take pride in enabling the best work of others on the team
- You are not afraid to grapple with the unknown and be innovative
- You have experience working in a fast-growing, dynamic company (or a strong desire to)
- You work hard and are not afraid to have a little fun while you do so
Our commitment to diversity, equity, and inclusion
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